Rhyl FC, who have a home tie with FK Atlantas in the UEFA Cup this week, will miss injured skipper Timmy Edwards and could also be without fellow defender Chris Taylor, who has valuable European experience from his time at TNS.
The Lithuanians also have problems with the recent resignation of their manager Igoris Pankratjevas, while in their doemstic league they have taken just three points in the last seven games.
Rhyl boss John Hulse is hoping his side will have too much firepower with Andy Moran likely to be paired with new signing Tommy Mutton.
"We're hoping a good crowd will get behind us on the night and give us something to take into the second leg," said Hulse.