"I won't be fit in either Wales game, which is a real blow," Gabbidon said. "Now I must concentrate on getting back to help West Ham's fight against relegation.
"It is very disappointing for me to miss the Wales games, I was looking forward to them, particularly the first soccer match at Croke Park against the Irish."
Ryan Giggs survived Man Utd's FA Cup win on Monday night and will lead the Welsh out against the Irish.