The Celtic midfielder will bring up his half-century if involved in Saturday's friendly against Finland at Cardiff City Stadium, having made his debut back in 2005 against Poland.
While now plying his trade in Scotland, Ledley came through the ranks at Cardiff before making his move to the Bhoys in 2010, and is grateful of the chance to bring up his landmark in his hometown.
"I am absolutely delighted and buzzing for Saturday. It's a great honour for me and my family so I am looking forward to it and hopefully getting on the pitch for it," he said.
"It's special for it to be at Cardiff City Stadium, where I came through the ranks and learnt all my football.
"When I was a kid I just wanted to play football and go out there and show the world I could do it.
"A lot of people do not make it to play for their country and it's a fantastic honour, and I try to do it as well as I can."
And the 26-year-old insists his appetite for pulling on the red shirt is undiminished from when he was first given the chance to wear it eight years ago.
"I definitely want to turn up and play for Wales," he said. "It's a great honour and I have loved every minute. Whenever we meet up I have great banter with the lads.
"Obviously you miss your family but it's football, you have to do it, that's your job and I look forward to going out and playing for my country."
Should Ledley feature in Chris Coleman's starting line-up, as the Wales boss takes charge with the security of a new two-year contract in his pocket, he will be likely to line up alongside former Cardiff colleague Aaron Ramsey.
The Arsenal man has made a stunning start to the season, scoring 13 goals for club and country and helping the Gunners to the top of the Premier League table.
And Ledley is not surprised at the form Ramsey is producing.
"I worked with him and we played together at Cardiff and I knew he was going to be a fantastic player," he said.
"Some people have criticised him but I felt he was still doing well. Now he is doing fantastic, adding goals to his game and showing how good he has always been. I'm just glad to see him doing well."