Joining West Ham's Gavin Williams on the injury withdrawl list is Blackburn Robbie Savage who misses out with a groin strain and influential winger Ryan Giggs.
Giggsy was expected to captain the side as he earns his 50th cap for Wales, however, has now returned to his club to recover.
Toshack's squad is further hampered as John Hartson has a back problem while defenders Danny Gabbidon and Gareth Roberts also have respective injuries.
Despite the late withdrawls, it is expected that no further players will be called up followinf the call up of Wrexham defender Steve Roberts who has yet to earn his first Wales cap.
Toshack has several problem at the back with Delaney out and John Collins captaining the U21 squad in Wrexham for tonight's game with Germany U21.
Wales new boys Danny Collins and Dave Partridge are expected to make their