Wayne Hennessey could make his first start for Wales in Saturday's Euro 2008 qualifier with the Czech Republic.
The 20-year-old Wolves goalkeeper made his debut as a substitute in last Saturday's friendly with New Zealand.
Danny Coyne has been struggling with a swollen knee this week, leaving Hennessey as the only genuine option.
Gareth Bale has been ruled out of the Cardiff match with an ankle injury, but Jason Koumas and Lewin Nyatanga are back after missing Saturday's draw.
Derby's Nyatanga, like Koumas on play-off duty last weekend, is likely to play on the left of a three-man central defensive line up, with James Collins on the right and Danny Gabbidon as sweeper.
Gabbidon looked out of touch in his first competitive match since January on Saturday, but Wales manager John Toshack sees the West Ham man as the key man in Wales's defence.
Joe Ledley is favourite to take Bale's place as left wing-back, with Sam Ricketts occupying the right flank.
Koumas will return to the midfield alongside Carl Robinson and Simon Davies, as captain Ryan Giggs plays his 64th and final international for Wales as a roving support striker behind Craig Bellamy.
Defeat against joint Group D leaders Czech Republic will realistically end Wales's hopes of qualification, despite having half of their group games still to play.
Defenders Danny Collins (hip), Mark Delaney (knee) and uncapped striker Freddy Eastwood (back) are unavailable because of injury.
Possible Wales team: Hennessey, Ricketts, J Collins, Gabbidon, Nyatanga, Ledley, Robinson, Davies, Koumas, Giggs (capt), Bellamy.
Wales squad: Danny Coyne (Burnley), Wayne Hennessey (Wolverhampton Wanderers), Lewis Price (Ipswich), Jason Brown (Blackburn), Gareth Bale (Southampton), James Collins (West Ham), Neal Eardley (Oldham), Steve Evans (Wrexham), Danny Gabbidon (West Ham), Chris Gunter (Cardiff), Craig Morgan (Peterborough), Lewin Nyatanga (Derby County), Sam Ricketts (Hull), Andrew Crofts (Gillingham), Arron Davies (Yeovil), Simon Davies (Fulham), Carl Fletcher (Crystal Palace), Jason Koumas (WBA), Joe Ledley (Cardiff), Carl Robinson (Toronto FC), Craig Bellamy (Liverpool), Rob Earnshaw (Norwich), Ryan Giggs (Manchester United), Daniel Nardiello (Barnsley), Chris Llewellyn (Wrexham).
BBC