Garry Monk, Andy Gurney and Lee Thorpe are all out, while Marc Goodfellow, Kevin McLeod, Andy Robinson and Sam Ricketts should be fit to play.
The game, which will be Alan Curtis' testimonial has attracted a reduced 10,000 capacity for the first game to be built at Swansea's state-of-the-art stadium and Fulham boss Chris Coleman has vowed to field a strong team.